When he powers on its game over
2022.01.22 14:17 PopApart2744 When he powers on its game over
2022.01.22 14:16 Saadking11 My chromebook crashed
any suggestions what I should do? Im tempted to throw it down the stairs
submitted by Saadking11 to teenagers [link] [comments]
2022.01.22 14:16 Rubix144 Can’t join CoOp
Does anybody have a new solution for this? We can only join on one friend.
Can’t find any new/recent solutions online.
submitted by Rubix144 to snowrunner [link] [comments]
2022.01.22 14:16 PrettiKinx If this ain't the truth!!
2022.01.22 14:16 pincy113 Meowster chief.
2022.01.22 14:16 Merrill-McMerlin A bluestreak cleaner wrasse
2022.01.22 14:16 freewatermel0ns Sex!!!!1++1!!
2022.01.22 14:16 JurassicCotyledon This sub is being overrun by spam
The crypto bashing spam is really hurting the general vibe and focus of this sub. I’m calling on the mods to please look at this issue more closely. I’m not suggesting that anyone invest in crypto, but this sub is turning into cryptobashing. I for one am not a fan.
Anyway, much love, and down with central banks.
submitted by JurassicCotyledon to Wallstreetsilver [link] [comments]
2022.01.22 14:16 ReviewOk5621 Controversial Opinion
2022.01.22 14:16 Samkazi23 [Rivalry Watch] Matchday 23 Serie A 2021/2021
Fixtures Saturday, 22nd January, 2022
Sunday, 23rd January, 2022
- Inter Milan vs Venezia
- Lazio vs Atalanta
- Cagliari vs Fiorentina
- Napoli vs Salernitana
- Empoli vs Roma
- Milan vs Juventus
|Rank ||Team ||Played ||Points |
|1 ||Inter ||21 ||50 |
|2 ||Milan ||21 ||48 |
|3 ||Napoli ||21 ||43 |
|4 ||Atalanta ||21 ||42 |
|5 ||Juventus ||22 ||41 |
|6 ||Lazio ||22 ||35 |
|7 ||Fiorentina ||20 ||32 |
|8 ||Roma ||22 ||35 |
submitted by Samkazi23
to ACMilan [link] [comments]
2022.01.22 14:16 frozengreatlake Vitamin B2: An "Overmethylation" Cure for Some
Abstract: Vitamin B2 (Riboflavin) supplementation might be a potential solution for “overmethylation” . A number of people have stated that taking a relatively high dose of the nutrient for a prolonged period has resulted in a cessation of negative side effects from relevant methylation or monoamine-related supplements. These anecdotes are listed below, along with related information:
Analysis of Primary Anecdotes:
- Daily Dose: (1) 400mg; (2) 200mg; (3) 400mg (4) 35mg split in 3 doses
- Timespan: (1) Months; (2) Unknown; (3) Months; (4) One Month
- Type (Riboflavin vs. R5P): (1) Riboflavin; (2) Riboflavin; (3) Riboflavin; (4) Riboflavin
- Side Effects: (1) Too relaxing; (2) None; (3) Unknown; (4) None
- 1, u/Dietoli Post
- Summary: He / she couldn’t handle methylation-related supplements until the implementation of B2 (and glycine). This commenter has since been able to continually handle creatine for multiple months.
- Key Statement: "I believed that I was a overmethylator. I reached this conclusion when I couldn't tolerate substances that directly or indirectly increase methyl groups. I decided to steer clear of any substance that increases methyl groups except riboflavin, I had to take riboflavin due to some other condition. I took immense amounts of riboflavin. Mega dosed riboflavin and took glycine too. After several months of doing this, one day I decided to try the creatine powder one more time when I found that trying methylcobalamin wasn't causing any difficulties. To my surprise it didn't give me bad symptoms. Now it has been almost a week or more, I have taken creatine everyday, once or twice, at least. It isn't bothering me at all. My conclusion is that I actually have undermethylation, not overmethylation, and taking creatine freed up methyl groups which worsened my symptoms initially. Riboflavin kept supporting the methylation process till I began to be able to tolerate methyl groups, so now creatine doesn't harm me anymore. I think my next course of action would be trying SAMe again.” 
- Side Effects: “It relaxed me a little too much” 
- Dosage: “Mega dose would be 400 mg / day” 
- 2, u/Mattyk128 Comment
- Summary: Doctor recommended B2 to increase tolerance of methylation-related nutrients.
- Key Statement: “I currently use hydroxyb12 (1000 mcg) and FOLINIC acid (400 mcg) and for my specific case i also use 200 mg of b2 (my doc suggested this as i was struggling to tolerate even the folinic acid at first” 
- Reasoning of Doctor: “She thought maybe I was deficient in B2 and it seems to be helping. I guess without sufficient B2 it can make it harder to methylate properly and the added B9 is just still clogging up the methylation? You basically need all parts working, not just one part.” 
- Side Effects: “I had no negative side effects.” 
- Dosage: “200 mg of b2” 
- 3, Neer's Phoenix Rising Post on “A List of Supplements to Avoid as Overmethylators”
- Summary: This person experienced “overmethylation” symptoms from a variety of supplements that he listed. After continual supplementation of B2 he was then able to tolerate all of the previously mentioned nutrients that caused trouble.
- Key Statement: “I am actually able to tolerate all these substances very well now. I no longer believe that I am an overmethylator, but I believe that I was a severe case of Undermethylation. As I supplied my body with methyl donating substances, it brought some changes which were quite difficult to tolerate initially. Hence I believe I was severely undrtmethylated. I took large doses of riboflavin, 400 mg a day for months, and I think it safely fixed my methyl group shortage, and I find that I can easily tolerate all the above mentioned substances now.” 
- Overmethylation: “What I do know is that these substances wrecked havoc in my health. Although substance that is meant to absorb the excess methyl groups, glycine, gave me enormous relief.” 
- Theory: “I think what's worth mentioning is that other methyl donors too could have brought me to the place where I am, but riboflavin worked for me over others because it really chilled me out unlike other methyl donors which made me angry / irritable. My personal theory is that it chilled me out because it speeds up the MAOA expression, which metabolizes serotonin and adrenaline.” 
- Type: In another post he mentioned that he takes riboflavin and not R5P
- Side Effects: Unknown
- Dosage: 400mg a day
- 4. Sherpa on Phoenix Rising
- Summary: He provides numerous posts and comments about how B2 supplementation has allowed him to beat “overmethylation”
- Key Statement: “I took the B2 in small doses (minimum 5mg) 3x a day for at least 4 weeks. In my case I started off a LOW POTENCY NatureMade B-complex in the morning, and a small piece of a B2 tablet with lunch and dinner. the lower dose B-complex was mellow, and constant saturation with B2 normalized my MAO A issues (uncomfortable reactions to methylation supplements, sleep disturbances, anxiety). Your "bit too much" reaction to Jarrow B-right sounds like a classic MAO A R297R +/+ reaction. In my case, many supplements were "too much" and created anxiety and uncomfortable feelings. After about 4 weeks of riboflavin 3x daily, my MAO A enzyme started working properly THEN I could go back and take B-complexes containing methylfolate... like B-right... and not be overstimulated. It just felt real nice” 
- Notable Quote: “Before adding B2 I got uncomfortably overstimulated by large doses of B12 and even small doses of methylfolate.” 
- Side Effects: “I didn't have any problems with B2 - I was deficient and, if anything, my body welcomed it.” 
- Dosage: 35mg split over 3 doses
Type: B2 vs. R5P
- 5. u/sodumb4real Comment
- Summary: Vitamin D is implicated in “overmethylation” as it can produce this negative state potentially due to its related impact on monoamine levels; the writer explains how B2 got ride of these side effects.
- Statement: “I don’t know how common it is, but I was getting bad reactions to vitamin D until I added Riboflavin” 
- 6. u/BananaMonkey7 Post
- Summary: The MAO gene is suggested to be a key factor of “overmethylation” given its purpose of degrading monoamines. B2 is a cofactor to it and the commentor suggests that a high dose of this nutrient helps diminish the irritability “overmethylation” side effect.
- Statement: “I also have the MAO warrior gene, if I get too irritable I will have to mega dose B2 to feel relaxed” 
- 7. Crux's Phoenix Rising Comment
- Summary: Commenter suggested that B2 is helpful for remedying “overmethylation”.
- Statement: “Regular B2, riboflavin, is still helpful, as well as niacinamide” 
- 8. u/Dietoli Comment (Different post than noted above)
- Summary: He / she states that B2 helps stop obsessive thoughts, a symptoms of “overmethylation”.
- Statement: “I have also tried Riboflavin upto 600 mg in a day, as three doses of 200 mg. It is very good too. Both of them chill me out and get rid of obsessive, ruminating, repetitive thoughts.” 
- Explanation: Riboflavin (B2) gets converted to riboflavin 5'-phospate (R5P) to be utilized by the body. Some people supplement R5P, but it does not seem that this is recommended for “overmethylation” purposes. All of the key anecdotes used the regular B2 form, and, in addition, there was an interesting comment that suggested they are not interchangeable:
- Quote: “Be warned that b2 absorption is not linear after 30 mg. It saturates pretty quickly. 100 mg at once might net you 40-50 mg total. That is why I thought to split doses and bam. R5p sodium has no such saturation and high oral bioavailability which is probably why it was so devastating to switch to 100 mg of that almost a year ago.” 
- Counter: Chris Masterjohn, along with some others, suggests that R5P is potentially worse to supplement with, not because it has a different bioavailability, but, rather, because the body has to convert it back to the simple riboflavin form to absorb this nutrient properly. He suggests taking regular B2 for this reason 
- B2 as cofactor to MAO enzyme
- Explanation: One key theory behind “overmethylation” is the dysregulation of monoamine levels with methylation-related nutrients overproducing monoamines such as dopamine and serotonin. Monoamines are typically degraded by the MAO enzyme (note: catecholamines are also broken down by the COMT enzyme). B2 is a central cofactor of the MAO enzyme.
- Quote: “One thing I forgot about the MAOA gene is that B2 is a cofactor so I find it’s important to get enough to keep my [neurotransmitters] balanced” 
- Quote: “My personal theory is that it chilled me out because it speeds up the MAOA expression, which metabolizes serotonin and adrenaline” 
- Sherpa’s Statements:
- “The most common reason for people to respond poorly to methylfolate is vitamin B2 deficiency.” 
- “Lack of B2 in combination with MAO +/+ means that your ability to turn off your neuronal stimulus is greatly reduced, thus leading to 'apparent' over-stimulation of nerves” 
- “MAO requires a metabolite of B2 called FAD to be present when the enzyme is synthesized.” 
- “It normally takes 2-4 weeks of regular B2 supplementation (e.g. 5mg or more, 3x daily) to normalize activity of MAO. This is provided that you have normal thyroid function.” 
- B2 Drives Proper Methylation
- Explanation: This nutrient is central to the methylation process to the point where some individuals have theorize that it is the key vitamin for most methylation issues. Some commenters suggest that supplementation of methylation-related nutrients could be depleting B2.
- Quote: “Methyl-B9 and Methyl-B12 act as ‘cushion’ for the methylation cycle and give the body enough so that it doesn’t have to make as much. Supplementing the 2 don’t actually fix the underlying issue by they’re still valuable. B-2 however is the cofactor that allows reactions to happen as quickly as the body needs. . . oversupplementing methylfolate, methyl-b12 simply creates more opportunities for our altered system to fail and necessitates greater use of B-2. Really, B2 and the Methylfolate (I take 1000mcg, or 1mg) together are the core of the treatment.” 
- Quote: “I ran out of B2 twice when I fired up methylation. The first time my tongue swelled and split – horrible. The second I had a rash on my face and privates, cracks at the corners of my mouth and angry capillaries in my eyes” 
- B2 Potentially Supports Glycine Storage (Helps GNMT function)
- Explanation: Methylation is said to be balanced in the body by the GNMT enzyme, which uses glycine to offset excess SAM-e. One comment suggested that B2 might help with the storage of glycine.
- Quote: “However, I seem to need more active b2 to avoid overmethylation. (Helps to drive mthfr and store glycine appropriately and buffer methyl donors, I think.)” 
- Quote: “After discovering that B2 lifts "folate-trap," I only take B2 and methylfolate in small amounts. I don't require extra B12. Once I fixed the B2 deficiency, B12 and methyfolate became much more potent. Even a small amount of B12 will trigger acetylcholine overload, so will TMG and creatine. What are the possible causes of this? Low homocysteine? BHMT pathway overactive? What should I be taking/avoiding? A few people online reported they got excess acetylcholine from being overmethylators, and they fixed it by supplementing niacin. It's possible that I'm an overmethylator (despite having MTHFR), but folinic acid doesn't work very well for me, even when coupled with B2.” 
- Quote: A post titled “Vitamin B2 causing headaches for anyone else” had this reply - “Happened to me. Headache and troubles falling asleep, which I would suspect are overmethylation symptoms?” 
- Quote: “since starting riboflavin, I can't tolerate any methyl b12 of methylfolate. it is incredibly strong. maybe all I needed was riboflavin this whole time. I can only take like 5-10 mg every three days. and it seems no one makes a riboflavin supplement in less than 50 mg doses 
Check out overmethylation
- a new community created to discuss this problem and find a solution. Sources
submitted by frozengreatlake
to Supplements [link] [comments]
2022.01.22 14:16 district69family Social Lites 59k plus rapidly growing social active text chat and active voice call social discord server
2022.01.22 14:16 BROTALITY Week 4: On A Stick - Lollipop Chicken
2022.01.22 14:16 amanu0 Jack when a new playbutton is revealed 0_0
submitted by amanu0 to JackSucksAtLife [link] [comments]
2022.01.22 14:16 EestiMentioned [/r/cryptostreetbets] Centaurify - Launching Now on BSC
submitted by EestiMentioned to EestiMentioned [link] [comments]
2022.01.22 14:16 ZoobBot 202567
This is the 202567th time I made this shitty comment. I hate this job.
submitted by ZoobBot to shittyjobsforrobots [link] [comments]
2022.01.22 14:16 SnooWoofers7603 This is emergency!
I want to say that I don’t know if I have Monotheism and sincerity in my heart, and I fear that I might have insincerity and polytheism in my heart.
And I don’t know what should I do in this case.
How can I be sure and certain about my heart? How can I activate my heart?
submitted by SnooWoofers7603 to therapy [link] [comments]
2022.01.22 14:16 huseyinozkan R E A L I T Y
2022.01.22 14:16 josef_aaaa XD
2022.01.22 14:16 TheSun-Loves-TheMoon My fiancé and I are eloping in Skye… what shoes do I wear? Haha
So I have a beautiful wedding dress, but I can’t share photos of it because he browses these subs as well and shared this account with me. But just know it’s a proper wedding dress.
We are eloping in Isle of Skye in Scotland and will be walking around quite a bit of rockiness and grassy meadows during the ceremony and for the photos.
Obviously this means heels are out as they would simply sink right into the earth or possibly trip me up on rocky outcrops.
We’re looking at a pair of all white Doc Martin boots, but is that crazy to have as my wedding shoes? I do really love combat style boots and have been wearing them for years. Ironically it would be very “me” to be wearing boots under my gown.
I’m just wondering if there’s anything I’m not thinking about if I were to go with them. Will I be missing out on anything photo wise? Are there any more elegant alternatives I haven’t considered?
Thank you for sharing any advice, thoughts, or suggestions you have.
submitted by TheSun-Loves-TheMoon to Eloping [link] [comments]
2022.01.22 14:16 Zucchini_Breath I got all the trinkets in the chest and now YouTube addresses are coming up. I have something to do this morning but I'm really excited about seeing what they are!
2022.01.22 14:16 ItsNarek Choose
2022.01.22 14:16 Infiniguana Damn, Caleb. You’re gonna make me act up
2022.01.22 14:16 m1ke_89 Receiver has been deactivated without being blocked?
Hello, My name is Miguel. I have a big question regarding something that happened last night and that probably lead to a big misunderstanding with the most important person of my life.
At some point last night I was getting the next message in chat: receiver has been deactivated". I thought it was an app problem so I tested in the web site but message were impossible to deliver. At that point I thought about being blocked but I was still able to see her posts and comments and upvote them. Also this morning I created a different account to see if deactivating message could lead to the same message, so I started a chat with that account then deactivated the new chat messages but I was still able to send messages to that account.
So I'm wondering what could possibly happened! Because now I'm so broken thinking all could be a misunderstanding.
Thanks in advance.
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2022.01.22 14:16 ZacBobisKing What happened to opening videos in the YouTube app?
Why did you have to remove it tho
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